The Wilds Bunch
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Dr.
Christopher
J. Wilds: Associate Professor and Canada Research Chair in Biological Chemistry. e-mail: cwilds@alcor.concordia.ca |
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Dr. Anne M.
Noronha: Research Associate. e-mail: anoronha@alcor.concordia.ca |
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Derek
O'Flaherty: Co-op student, summer 2008. Synthesis of O4 alkyl thymidine analogs. |
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Nadia
Schoonhoven: |
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Gang
Sun: New methods to synthesize chemically-stable analogs of interstrand cross-linked DNA using organo-metallic reactions. These molecules will be used to study DNA repair pathways. Synthesis of modified thymidine nucleosides for single molecule biophysics experiments. |
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Francis
McManus: Synthesis of interstrand X-linked DNA duplexes with linkers designed to mimic lesions formed by certain chemo-therapeutic agents on DNA. The duplexes will be examined for their ability to serve as substrates or inhibitors of repair pathways such as that by human alkylguanine- DNA alkyl-transferase (hAgt). |
Past Members |
| Ernest
Palus: M.Sc. student (09/2003 - 07/2007). Synthesis of 7-deaza-deoxyguanosine analogs as probes to investigate DNA repair. |
Jason Booth: M.Sc. student
(05/2006 - 01/2008). |
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Xu Fei: B.Sc. Honours student (01/2007-08/2007). |
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Sebastian
Murphy: NSERC Undergraduate Summer Research Student (2007 and 2008). Synthesis of modified DNA to probe the origins of resistance to chemo-therapeutic agents. |
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Amardeep Khaira: Synthesis of a cross-linked nucleoside dimer that will be incorporated into a DNA duplex. The molecule will be used in DNA repair studies using both human alkyl-guanine- DNA alkyltransferase (hAgt) and O6-alkyl- guanine-DNA-alkyltransferase (Ogt) from E. coli. |  |
Sabrina
Taddeo: B.Sc. Science College 390 project (May - August 2007). Non-radioactive detection of DNA bending using an electrophoretic mobility shift assay. |
| Amira Mohamed: Ph.D. student (co-supervised with Dr. R. Roy - UQAM). Extraction, purification, structural characterization and biological properties of jojoba extracts (Simmondsia chenensis). |
| Virginie Placide: Ph.D. (co-supervised with Dr. R. Roy - UQAM). Synthesis of the breast cancer marker Thomsen-Friedenreich antigens in forms suitable for vaccine and dendrimer preparation. |
| Subhash Rauthu: Ph.D (co-supervised with Dr. R. Roy - UQAM). Design of selective ligands for conjugate drug targeting to human serum albumin (HAS) through cysteine-34 and -D-galactopyranoside inhibitors. |
| Jason Moscovici: B. Sc. Chem 419 (09/2004 - 04/2005). Synthesis of chemically modified nucleosides for use as anti-sense therapeutic agents. |
| Michael Wamberg: Ph.D. student (visiting from Odense University, Denmark, 02/2005 - 08/2005). Synthesis of C8 adducts of guanosine. |
| Rafael Languay: B.Sc. Honours project (co-supervised with Dr. S. Robidoux, 09/2004 - 04/2005). Naphthalene diimide derivatization and incorporation into an oligonucleotide. |
| Alexander Tandel: B.Sc. Chem 419 (01/2006 - 04/2006). Investigation of triplex formation of a novel branched oligonucleotide. |
| Alexander Seelig: B.Sc. Science College 390 project (01/2005 - 04/2005). Evaluation of the Thermal Stability of Oligonucleotides containing a Phenyl-Ring Base Analog by UV-melting Experiments. |
| Hao Peng: B.Sc. Co-op work term (05/2004 - 08/2004). Synthesis of nucleosides containing the sugar threose. |
Some Group Photos
Amardeep Khaira, Francis
McManus, Anne Noronha, Nadia Schoonhoven, Sebastian
Murphy, Chris Wilds, Gang Sun (May
15, 2009).
Back row: Gang Sun, Chris Wilds, Francis McManus, Nadia Schoonhoven.
Front row: Amardeep Khaira, Derek O'Flaherty, Anne Noronha, Sebastian Murphy (October 24, 2008).
Graduation: Xu Fei, Chris Wilds, Ernest Palus and Sabrina Taddeo (November 11, 2007).
Back row: Gang Sun, Chris Wilds, Francis McManus, Nadia Schoonhoven.
Front row: Amardeep Khaira, Derek O'Flaherty, Anne Noronha, Sebastian Murphy (October 24, 2008).
Graduation: Xu Fei, Chris Wilds, Ernest Palus and Sabrina Taddeo (November 11, 2007).
