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Chris Wilds - Publications

Selected papers:

Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Fang, Q., Noronha, A.M., Murphy, S.P., Wilds, C.J., Tubbs, J.L., Tainer, J.A., Chowdhury, G., Guengerich, F.P., Pegg, A.E. (2008), Biochemistry, Oct 14; 47(41): 10892-903.

Synthesis, biophysical and repair studies of O6-2'-deoxyguanosine adducts by Escherichia coli OGT. Schoonhoven, N.M., Murphy, S.P., O'Flaherty D.K., Noronha, A.M., Kornblatt, M.J., Wilds, C.J. (2008), Nucleic Acids Symp Ser (Oxf). (52): 449-50.

Effect of linker length on DNA duplexes containing a mismatched O6-2'-deoxyguanosine-alkyl interstrand cross-link. Booth, J.D., Murphy, S.P., Noronha, A.M., Wilds, C.J.(2008), Nucleic Acids Symp Ser (Oxf). (52): 431-2.

Distortion-dependent unhooking of interstrand cross-links in mammalian cell extracts.  Smeaton, M.B., Hlavin, E.M., McGregor Mason T., Noronha A.M., Wilds, C.J., Miller, P.S. (2008), Biochemistry, Sep 16;47(37): 9920-30.

Synthesis and characterization of DNA containing an N1-2'-deoxyinosine-ethyl-N3-thymidine interstrand cross-link: a structural mimic of the cross-link formed by 1,3-bis-(2-chloroethyl)-1-nitrosourea. Wilds CJ, Xu F, Noronha AM. (2008) Chem Res Toxicol. 21(3):686-95.

Wilds, C.J., Palus E. and Noronha A.M. (2007) "An Approach for the Synthesis of Duplexes Containing N3T-Alkyl-N3T Interstrand Cross-links via a Bisphosphoramidite Strategy", Canadian Journal of Chemistry, 85, 249-256.

Wilds, C.J., Booth, J.D., Noronha, A.M. (2006) "Synthesis of Oligonucleotides Containing an O6-G-alkyl-O6-G Interstrand Cross-Link", Tetrahedron Letters, 47, 9125-9128.

Li, F., Sarkhel, S., Wilds, C.J., Wawrzak, Z., Prakash, T.P., Manoharan, M and Egli, M. (2006) "2'-Fluoroarabino- and arabinonucleic acid show different conformations, resulting in deviating RNA affinities and processing of their heteroduplexes with RNA by RNase H", Biochemistry, 45, 4141-4152.

Wilds, C.J., Maier, M.A., Manoharan, M. and Egli, M. (2003) "Structural Basis for Recognition of Guanosine by a Synthetic Cytosine Analogue:  Guanidinium G-Clamp", Helvetica Chimica Acta, 86, 966-978.

Wilds, C. J., Wawrzak, Z., Krishnamurthy, R., Eschenmoser, A. and Egli, M. (2002) "Crystal Structure of a B-form DNA Duplex Containing (L)-α-Threofuranosyl (3'->2') Nucleosides:  A Four Carbon Sugar is Easily Accommodated into the Backbone of DNA", Journal of the American Chemical Society, 124, 13716-13721.

Quan Du, Nicolas Carrasco, Marlanna Teplova, Christopher J. Wilds, Martin Egli, and Zhen Huang* (2002), ÒInternal Derivatization of Oligonucleotides with Selenium for X-ray Crystallography Using MADÓ, Journal of American Chemical Society, 124, No. 1, 24-25.

Marianna Teplova, Christopher J. Wilds, Quan Du, Nicolas Carrasco, Zhen Huang, and Martin Egli* (2002), "Covalent Incorporation of Selenium into Oligonucleotides for X-ray Crystal Structure Determination via MAD: Proof of Principle",  Biochimie, 84, 849-858.

Last revised: December 17, 2009 (ostee)